Inhibition of Cdk1 and Cdk2 by 6,7,4′-trihydroxyisoflavone inhibited growth of HCT-116, a human colon cancer cell line [11], and JNJ-7706621, an inhibitor of Cdk1/cyclinB1 and aurora kinase effectively reduced growth of transplantable liver tumor in combination treatment with paclitaxel [12]. The gene discussed is CDK1; the disease is malignant colon neoplasm.