CD1D and B-cell chronic lymphocytic leukemia: In particular, it will be interesting to test cytotoxicity of these cells upon modulation of CD1d on CLL cells and whether restoration of CD1d on CLL in vivo could be accomplished by immunomodulatory drugs such as lenalidomide, which was recently shown to reconstitute several immune dysfunctions associated with CLL [1, 3, 5, 6].