However, staining splenocytes of sacrificed leukemic mice with TCR-Vβ-specific antibodies revealed that the severe T cell skewing that is usually associated with CLL development in TCL1 mice was absent in CD1d−/− TCL1 mice, especially within the DN compartment (Figure 5B and Supplementary Table S4). Here, CD1D is linked to B-cell chronic lymphocytic leukemia.