Mice which downregulated CD1d on CLL cells (recipients receiving spleen #249) showed a faster tumor growth and died significantly earlier from leukemia than mice which preserved high CD1d expression (recipients receiving spleen #250) (TCL1 Tx CD1dhighn = 4; TCL1 Tx CD1dlown = 4; Log-rank Mantel Cox test p = 0.0062; Hazard Ratio 20.95; 95% Confidence Interval = 2.376 to 184.7; Figure 6C and Supplementary S6A, middle and right panel; cohort 2 + 3). Here, CD1D is linked to leukemia.