In TCL1 mice, CD8+ T cells expressing these cytokines were specifically enriched within the NK1.1+ subset (Supplementary Figure S3A) while in CLL patient samples, DN and CD8+ T cells exhibited increased cytokine production within the CD161+ fraction, except for IL-4 (Supplementary Figure S3B). This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.