To investigate if combining anti-CD40 mAb therapy with sunitinib treatment affects tumor endothelial cell activation, we studied the surface expression of the intercellular adhesion molecule 1 (ICAM-1) and the vascular cell adhesion molecule 1 (VCAM-1) in B16.F10 and T241 tumor-derived endothelial cells. This evidence concerns the gene CD40 and neoplasm.