Consistent with VEGF-stimulation of tumor endothelial cells being associated with lower expression of endothelial activation markers, B16.F10 tumors express higher levels of VEGF and lower levels of endothelial ICAM-1 and VCAM-1 than T241 tumors (Figure 4A-4D, Supplementary Figure S4A). This evidence concerns the gene ICAM1 and neoplasm.