Across the data sets, cophenetic coefficient analyses showed that irrespective of the morphological diagnosis, glioma samples were stably and reproducibly clustered into the RMPAhigh subtype which has high expression of SPRY-M and low expression of NF1-M and PTEN-M, and the RMPAlow subtype with a reversed expression pattern of the three modules (Figure 1, Supplementary Figures S1, S2). This evidence concerns the gene PTEN and central nervous system cancer.