Confocal analyses of the co-staining showed that in addition to glioma cells, high RTK signaling activities were detected in vessel cells and infiltrating TAMs in RMPAhigh gliomas; weak or barely detectable p-AKT activity in CD68+ or CD31+ cells was observed in RMPAlow gliomas (Figure 5, Supplementary Figure S11). Here, AKT1 is linked to central nervous system cancer.