EPHB4 and central nervous system cancer: Due to an amplicon at chromosome 7q, about 9% of the RMPAlow gliomas harbored amplifications of MET, EPHA1, EPHB4, EPHB6, and BRAF. Another amplicon at 12p13 in 12% of the RMPAlow gliomas resulted in co-amplifications of FGF6, FGF23 and NTF3. A third amplicon at 1q22 to 1q23 resulted in co-amplification of NTRK1, INSRR and SEMA4A.