Among the 166 RMPAhigh gliomas, 88 harbored focal amplification of EGFR, and 35 of these EGFR amplifications also harbored mutations in EGFR; an additional 7 RMPAhigh gliomas harbored EGFR mutations without detectable focal amplification (Supplementary Table S6). This evidence concerns the gene EGFR and central nervous system cancer.