Co-occurrence between amplification of EPHB3 and alterations in PIK3CA (both at chromosome 3q26-3q27), and amplifications in PDGFRA, KIT and KDR (all at 4q12) were also found in a subset of RMPAhigh gliomas (Supplementary Table S7), due to their localization in the common amplicons (Supplementary Figure S6). The gene discussed is PIK3CA; the disease is central nervous system cancer.