In the RMPAlow gliomas, a different set of RTK signaling-related genes including MET (8.9%), EPHA1 (8.9%), EPHB6 (8.9%), EPHB4 (8.3%), BRAF (8.9%), FGF6 (11.9%), FGF23 (11.9%), NTF3 (11.9%), and ANGPT1 (9.5%) were amplified (Supplementary Table S6). This evidence concerns the gene EPHB6 and central nervous system cancer.