AREG and central nervous system cancer: At a statistical significance of p = 10−6 and q values ranging between 2.0 × 10−6 and 3.9 × 10−7 (and concordant expression pattern in at least four data of the five data sets analyzed), the ligands to EGFR (AREG with > 10-fold higher expression in the RMPAhigh gliomas, and EGF) were found enriched in the RMPAhigh gliomas, which may have contributed to enhanced EGFR signaling in RMPAhigh gliomas irrespective of EGFR alteration.