Unlike the RMPAhigh gliomas, the RMPAlow gliomas showed enriched expression of ERBB3, ERBB4, FGF9, FGF12, FGF13, FGF14, NTRK2, NTRK3, together with a different set of ephrins and Eph receptors (EFNA3/EPHA10, EFNB3/EPHB6, EPHB1), as well as members of SEMA3/SEMA4 family and PLXNB family (Supplementary Figure S7 and Supplementary Table S9). Here, ERBB4 is linked to central nervous system cancer.