Though gliomas with RMPAlow signature contained fewer CD45+ cells and CD105+ cells, CD45+ cells in these gliomas also expressed VEGFR1, KDR, EPHB4 and PLXNB2 (Figure 4, Supplementary Figures S9B, S10 and Supplementary Table S11). This evidence concerns the gene PLXNB2 and central nervous system cancer.