Besides VEGF-related pro-angiogenic factors (VEGFA with ~ 9-fold higher expression in the RMPAhigh gliomas, and VEGF co-receptor NRP1 and NRP2), high expression of additional pro-angiogenic factors including ANGPT1 and ANGPT2, EPHA2/EPHB2, EFNB2/EPHB4, PDGFA/PDGFD/PDGFRB and SEMA3A/SEMA3F/PLXNA3/PLXNB2 [42] was found in RMPAhigh gliomas. Here, ANGPT2 is linked to central nervous system cancer.