Though gliomas with RMPAlow signature contained fewer CD45+ cells and CD105+ cells, CD45+ cells in these gliomas also expressed VEGFR1, KDR, EPHB4 and PLXNB2 (Figure 4, Supplementary Figures S9B, S10 and Supplementary Table S11). The gene discussed is FLT1; the disease is central nervous system cancer.