NFKB1 and B-cell chronic lymphocytic leukemia: Of note, we recently identified by GEP cell death and NF-κB among the top pathways regulated by BV6 in responsive primary CLL samples as well as in primary core-binding factor (CBF) AML samples [38], underscoring the general relevance of these signaling pathways for Smac mimetic-mediated antitumor activity.