We previously demonstrated in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) that small-molecule antagonists of IAP proteins can sensitize cells for Tumor-Necrosis-Factor-related apoptosis-inducing ligand (TRAIL)-, CD95- or chemotherapy-induced apoptosis [13–16]. The gene discussed is FAS; the disease is B-cell chronic lymphocytic leukemia.