In hepatocellular carcinoma, PRC2 complex epigenetically repressed miR-101 in a c-Myc-mediated manner, which in turn inhibited the expression of two subunits of PRC2 (EZH2 and EED), thus creating a double-negative feedback loop that regulates the process of carcinogenesis [17]. This evidence concerns the gene EED and hepatocellular carcinoma.