To this end, murine liver cells harboring a genetic lesions in MAVS (also known as CARDIF, IPS-1, VISA) and containing all minimal factors required for HCV replication and infection (MLT-MAVS−/−miR-122/mmmmm [33]), were transfected with HCV SGR RNA and cocultured either with the mixed Flt3-L culture or purified murine Flt3-L derived DC subsets. The gene discussed is MAVS; the disease is infection.