KLF4 and cardiac hypertrophy: Among these genes, Klf4 alone had a significant cis-eQTL at SNP rs27794497 (p-value = 5.9 x 10−5) and was significantly correlated with LVM hypertrophy at week 3 (bicor = -0.3, p-value = 0.0088; S8D and S9 Figs).