To further examine the role of AKR1C3 in radiation resistance, we used indomethacin to hinder AKR1C3 activation and examined the effects on the response of PCa cells to radiation treatment.As shown in Figure 2A, indomethacin has suppressed the expression of AKR1C3 protein. The gene discussed is AKR1C3; the disease is posterior cortical atrophy.