It is important to note that Igf-2 levels rapidly diminish after birth in rodents, thus further studies are needed to examine whether the increased islet growth seen in fetal MIP-βIRKO pancreas can be sustained in postnatal life and to determine whether these mice acquire postnatal glucose intolerance or develop innate protection against age-dependent islet mass degeneration [9, 11]. Here, IGF2 is linked to Glucose intolerance.