EPAS1 and Familial prostate cancer: RT-qPCR analysis of CXCL6 and EPAS1, two tumor promoting genes significantly more expressed in human prostate cancer versus normal tissue [52, 53] and induced by Notch1 in LNCaP and PC3 cells (Supplementary Table 2), were also found highly transcribed in the Notch1 resistant clones, like in the in vivo tumors with elevated Notch expression (Figure 5B).