SMAD3 and prostate adenocarcinoma: To confirm our findings in the clinical setting, we analyzed Notch1, p21WAF1/CIP1 and smad3 co-occurrence in the TCGA-PRAD dataset and found that Notch1 association with Smad3 was positive and statistically significant (p-value = 0.002) and that Notch1 showed a tendency towards co-occurrence with p21WAF1/CIP1 (p-value = 0.04).