The C-terminal SAP motif of KU70 mediates LSD1/SIRT1 competitive interaction by suppressing LSD1 binding to KU70 and ectopic expression of SAP-deleted KU70 to CML cells compromises their ability to acquire BCR-ABL mutations. This evidence concerns the gene XRCC6 and chronic myelogenous leukemia, BCR-ABL1 positive.