We carried out ChIP of active chromatin mark H4K16Ac in part as a positive control for KU70-SIRT1-LSD1 ChIP and to determine the impact of SIRT1 recruitment on local chromatin since BCR-ABL is actively transcribed in all CML cells. This evidence concerns the gene XRCC6 and chronic myelogenous leukemia, BCR-ABL1 positive.