Pathway analysis of the 50 gene NIT signature revealed enrichment for MAPK signalling (DUSP1, JUN, NR4A1 and FOS), cancer specific (COX-2, PGE2, JUN and FOS), apoptosis induction (FOS and JUN) and genomic reformatting following (brain) ischaemia (EGR1 and JUN) pathways. This evidence concerns the gene FOS and cancer.