Previously, Montagner et al. 28 showed that triple-negative breast cancer (TNBC) patients have better metastasis-free survival if their tumours express higher levels of BHLHE41. They went on to show that BHLHE41 inhibits the invasive and metastatic phenotype of TNBC by promoting the proteasomal degradation of HIF, independently of VHL28. Here, BHLHE41 is linked to triple-negative breast carcinoma.