Similarly, allele-specific expression differences were observed between rs10842708 and genes in close proximity on 12p12.1, namely, SSPN (trend test P value=2.5 × 10−4), ITPR2 (trend test P value=0.003) and RASSF8 (trend test P value=0.009; Table 1 and Supplementary Fig. 5b–d) in RCC, although the associations were substantially less than for BHLHE41. The eQTL between rs10842708 and BHLHE41 is specific to clear cell RCC (ccRCC) and is not observed in papillary RCC TCGA samples (Supplementary Fig. 6). Here, BHLHE41 is linked to nonpapillary renal cell carcinoma.