BHLHE41 and renal cell carcinoma: The G allele of rs10842708 corresponds to the RCC risk allele and is strongly associated with increased expression of basic helix-loop-helix family, member E41 (BHLHE41, also known as SHARP1, DEC2 and BHLHB3; trend test P value=6.3 × 10−7) in RCC, but not in normal kidney tissue (Supplementary Fig. 5a).