Moreover, interaction between the endogenous circadian timing system and adipose function has recently been demonstrated30, and further work suggests that inhibition of adipogenesis by BHLHE41 through the regulation of C/EBP activity31 provides a basis for the link between BHLHE41 and obesity, a known RCC risk factor. The gene discussed is BHLHE41; the disease is obesity due to melanocortin 4 receptor deficiency.