The majority of the correlated, untested RCC SNPs localized to a non-coding region, which also overlaps with the 3′-UTR of the inositol 1,4,5-triphosphate receptor type 2 (ITPR2), a member of the second messenger intracellular calcium release channels and nearest plausible candidate gene (Fig. 1). Here, ITPR2 is linked to renal cell carcinoma.