We did not observe an association between BHLHE41 mRNA expression levels and adverse pathologic factors: Fuhrman grade (Wald test P value=0.88), metastasis (Wald test P value=0.8), node involvement (Wald test P value=0.72) or tumour stage (Wald test P value=0.51). The gene discussed is BHLHE41; the disease is neoplasm.