The multivariate analysis of risk factors showed that high TNM stage (HR=3.428, 95%CI: 1.519-7.737, p=0.003) and low CDC25a expression (HR=2.384, 95%CI: 1.008-7.642, p=0.048) were independent prognostic risk factors in lung adenocarcinoma but not YBX1. The gene discussed is CDC25A; the disease is lung adenocarcinoma.