Simultaneously, high expression of YBX1 or CDC25a in 116 patients with lung adenocarcinoma had shorter 5-year overall survival than low expression (5-OS%:40.5% VS 74.9%, p=0.044 and 5-OS%:45.5% VS 79.7%, p=0.004, respectively). This evidence concerns the gene CDC25A and lung adenocarcinoma.