INSR and neoplasm: Thus, the C. vasculum compound 1 binds to IGF-1Rβ but not InsR or EGFR in NSCLC cells, and both compounds 1 and 2 impair IGF-1Rβ phosphorylation and cause IGF-1Rβ degradation thereby impairing oncogenic signaling in tumor cells resulting in prominent cell death.