Similarly, Krishnamoorthy et al. showed that in PCa cells exposed to hypoxia, the 12-lipoxygenase enzyme (12-LOX) up-regulated the HIF1α mRNA and protein expression, through the generation of the eicosanoid 12-HETE (12-hydroxyeicosatetraenoic acid) [73,74]. This evidence concerns the gene HIF1A and posterior cortical atrophy.