In vivo studies regarding humanin's neuroprotective role in Alzheimer's Disease (AD) mouse models showed that humanin administration to the triple transgenic mice, which contains three mutations associated with familial Alzheimer's disease, improved spatial learning while reducing memory deficits, Aβ plaque accumulation, and neuro-inflammatory response [17]. This evidence concerns the gene MT-RNR2 and early-onset autosomal dominant Alzheimer disease.