Sohlh2 expression was significantly lower in invasive ductal carcinoma with (n = 29) and without metastasis (n = 48) compared to intraductal carcinoma in situ (n = 16) and adjacent tissues (n = 25), with a median IHC-score 8.04 for adjacent tissues, 6.76 for intraductal carcinoma in situ, 4.96 for breast cancer without matastasis, and 3.6 for breast cancer with matastasis, respectively (p < 0.01; Figure 1B). Here, SOHLH2 is linked to in situ carcinoma.