Further to this, macrophage markers Lgals3, Fsp1, and Cd11b, known to be involved in the early modulation of NASH, were significantly increased, as were lymphocyte specific markers Cd8 and B220 in 11β-HSD1KO compared with controls (Figure 5, B and C). Here, ITGAM is linked to metabolic dysfunction-associated steatohepatitis.