COL1A1 and metabolic dysfunction-associated steatohepatitis: Because the pathogenesis of NASH involves the deposition of collagen and the formation of fibrotic lesions as hallmark features of advancing disease, we assessed the expression of fibrosis markers and show that Col1a1, encoding the major protein component of type 1 collagen, is significantly increased (P = .004) in 11β-HSD1KO but not in control livers.