When we tested the effect of myeloid TNF deletion in experimental stroke, we found LysMcreTNFfl/fl mice to have significantly increased FDG uptake acutely (>3 hours) and larger infarct volumes at 24 hours and 5 days after pMCAO, supporting our previous findings that constitutively expressed or early induced, microglial-derived TNF is neuroprotective in experimental stroke4. The gene discussed is TNF; the disease is Stroke.