The finding of increased FDG uptake in the ipsilateral hemisphere of LysMcreTNFfl/fl mice compared to TNFfl/fl mice during acute ischemia supports the findings of increased infarct volumes 24 hours and 5 days after pMCAO and demonstrate that conditional ablation of TNF in microglia modifies neuronal sensitivity to ischemia. The gene discussed is TNF; the disease is ischemia.