Our data showed that over-expression of RhoB remarkably induce the apoptosis of ccRCC cells, and increase apoptotic protein(casp3 and casp9) expression.Site-directed mutagenesis studies have defined the crucial requirement of palmitoylated cysteine 192 and prenylated cysteine 193 for tumor suppressive and proapoptotic activities of RhoB [37]. This evidence concerns the gene CASP9 and nonpapillary renal cell carcinoma.