To find other possible targets of miR-7a/b involved in MI, we used TargetScan and predicted miR-7a/b binding sites at the Sp1 3′UTR, and transfection with miR-7a/b mimics significantly inhibited Sp1 expression and resulted in a decreased luciferase activity of GV126-Sp1-3′UTR-WT. This evidence concerns the gene SP1 and myocardial infarction.