It has an essential role in B-cell homeostasis and in the development of several autoimmune diseases, (i.e. systemic lupus erythematosus, rheumatoid arthritis, primary Sjögren’s, myasthenia gravis, systemic sclerosis, Graves’ disease), furthermore BAFF blood levels were higher during different infectious diseases and its role in the maintenance of inflammation has been recognized1, 6, 7, 8, 9, 10. Here, TNFSF13B is linked to infectious disease.