We also tried to correlate circulating BAFF levels to antibody positivity against MAP and EBV infections previously found to be associated with MS14, 15, 16, 17, 18, 19.In previous studies, a stronger humoral response against two EBV peptides EBNA1400–413 and BOLF1305–320, the homologous mycobacterial peptides MAP_0106c121–132 and MAP_402718–32 and human homologues MBP85–98 and IRF5424–434 was detected in MS patients compared to HCs14, 15, 16, 17, 18, 19. This evidence concerns the gene TNFSF13B and myeloid sarcoma.