One segment covered VHL (3p25.3-3p25.1, from TTLL3 to CAPN7), while the other spanned ccRCC driver genes SETD2, PBRM1 and BAP1 (3p22.3-3p14.3, from CNOT10 to DENND6a) (Fig. 2A). The gene discussed is DENND6A; the disease is nonpapillary renal cell carcinoma.