AKT1 and cancer: Despite genetic divergence between two tumors in both bilateral ccRCC patients, non-synonymous and splicing site mutations in all four tumors displayed functional convergence on cancer-related pathways, including the ubiquitin-mediated proteolysis pathway, PI3K-Akt-mTOR signaling pathway, and other caner related pathways (Fig. 6 and Supplementary Table 7).