CASP3 and infection: To investigate the mechanism by which UPSA 807 induces cellular cytotoxicity in bladder cells, we assessed caspase-3 activiation in infected cells, which revealed a statistically significant but modest level of caspase-3 activation following infection with UPSA 807 in vitro; the equivalent response of significant caspase-3 activation did not occur following infection with ABSA 834 (Fig. 3).