Laboratory data showed hypochromic anemia with hemoglobin value of 9.3 g/dl and positive direct Coombs test, an increased erythrocyte sedimentation rate (ESR) of 120 mm/h and a C reactive protein (CRP) of 53 mg/dl; elevated serum levels of total proteins (9.1 g/dl) with hypergammaglobulinemia (42.4 %), decreased C3 and C4 complement factors concentrations and slightly elevation of AST (90 UI/dl); renal function, electrolytes, glycaemia, blood coagulation tests, tumor markers were within normal levels. This evidence concerns the gene CRP and neoplasm.