CD4 and disease arising from reactivation of latent virus: Given that R5-tropic HIV are the major transmitted viral strain [36–38], and therefore are the main strains that establish HIV latency [10], we also assessed the impact of increasing R5-tropic HIVNL4.3(AD8).EGFP titre on latent infection of unstimulated and mDC co-cultured resting CD4+ T-cells (Fig 3).