To validate this finding, we also treated cells with Reversine and chemical BI 2536, a specific inhibitor of Plk1 that has an established role in cytokinesis.44 Consistently, cotreatment with BI 2536 and Reversine causes a higher polyploidization but shows a lower tumor cell death ratio compared with the BI 2536 alone (Supplementary Figures 4d and e). The gene discussed is PLK1; the disease is neoplasm.