Apoptosis inducing activity was confirmed based on increased sub-G0 phase cell population in cell cycle analysis, loss of mitochondrial membrane potential, elevated levels of cytochrome c, nuclear morphological changes, and DNA fragmentation in MIA PaCa-2 pancreatic cancer cells [43]. B. flabellifer seed coat extracts were screened in another study [44] for their possible anticancer activity on growth of the HeLa cells and these preliminary studies indicated that even the lower concentrations of plant extract showed significant antiproliferative activity. Here, CYCS is linked to familial pancreatic carcinoma.