Antioxidant activities like restoring the levels of reduced glutathione (GSH) and the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), along with significant inhibition of both lipid peroxidation and myeloperoxidase (MPO) activity, have been seen with administration of methanolic extract of Acanthus ilicifolius leaf extract in different models of gastric ulceration. The gene discussed is CAT; the disease is gastric ulcer.