The increase in body weight in the add-on to insulin secretagogues group is presumably due to defensive eating secondary to the increased tendency to mild hypoglycemia in the SU and glinide groups; in the TZD group it is not clear why the usual increase in weight is exacerbated by the addition of vildagliptin when one considers its mechanisms to mitigate body weight [26]. This evidence concerns the gene INS and Hypoglycemia.