Bandopadhayay et al. used newly generated patient and genetically engineered mouse model-derived medulloblastoma cell lines and xenografts with MYC or MYCN amplifications to find that JQ1 suppresses MYC expression, MYC-associated transcriptional activity, and therefore decreased cell viability in medulloblastomas [44]. The gene discussed is MYC; the disease is medulloblastoma.