Neuroblastoma is frequently associated with amplification of MYCN, and bromodomain-mediated inhibition of MYCN attenuated growth and induced apoptosis, conferring a survival advantage in three in vivo models of neuroblastoma [37]. Lee et al. validated the antitumorigenic effects of JQ1 in neuroblastoma using monolayer and sphere-forming conditions in vitro and subcutaneous neuroblastoma xenografts in vitro. Here, MYCN is linked to neuroblastoma.