BRD4 also mediates transcriptional elongation and has been linked to c-MYC dependent transcription as well as positive transcription elongation factor complex (P-TEFb)-induced increased growth promotion [14-15]. The discovery of the roles of BRD4 and the other proteins in the bromodomain family established a rationale for targeting BET bromodomains to inhibit transcription, particularly in cancer cells. Here, BRD4 is linked to cancer.