DNER and cardiovascular disorder: RVX-208 is a BET inhibitor with preferred binding to the second bromodomains (BD2s), with highest selectivity observed for BD2 of BRD2 and BRD3. While the compound is currently being investigated in phase II clinical trials for cardiovascular diseases, Picaud et al. (2013) demonstrates the feasibility of specific targeting within the BET family resulting in different transcriptional outcomes [20]. Current inhibitors include BMS-986158, OTX015, and PLX-51107, among others in development; the mechanism of action of each of these inhibitors is slightly varied.