DMD and Duchenne muscular dystrophy: However, the exact role of dystrophin in the CNS as well as its contribution to the CNS phenotype of DMD patients is still a matter of debate and hampered by the complexity and high variety of the dystrophin isoforms and their DAPC components: Dp427 is expressed at the postsynapse of neurons in the hippocampus, cerebellum, and cerebral cortex [39–43].