SPP1 and metabolic syndrome: The five constituents of GAP-M seem to be reasonable in estimating pathophysiological extent of metabolic syndrome (BMI and T2DM) and liver fibrosis (Plt, γ-GTP, and ALP), as γ-GTP was reported to be a surrogate marker of TNF-α expression in the liver [15] and ALP seems to be closely associated with osteopontin expression in the liver (Supplementary Figures 1b–1d).