Virus infection induced an average increase of 152.23 ± 87,90%, 129.82 ± 81.01%, 83.79 ± 27.15%, and 40.86 ± 29.02% for NF-κB, COX-2, PDI, and Hsc70 expression, respectively, relative to villi from uninfected control mice during the 12–48 h.p.i. This evidence concerns the gene HSPA8 and viral infectious disease.