Here we show that the cellular proteins PPARγ, NF-κB, PDI, and Hsc70 and reactive oxygen species (ROS) were increased by in vivo and in vitro rotavirus infection of small intestinal villi, whereas their increased levels were returned close to basal ones, with concomitant reduction of viral infection, following treatment with PGZ and other PPARγ agonists. This evidence concerns the gene NFKB1 and viral infectious disease.