Increased or insufficiently buffered hydrogen peroxide production at the apical membrane of CF epithelia by NADPH oxidases, especially by the dual oxidase 1 (DUOX1) [283, 284], may increase metalloproteinase-mediated release of ligands that activate the ErbB1 signaling pathway resulting in augmented CXCL8 production [273, 285] (Figure 2(c)). This evidence concerns the gene DUOX1 and cystic fibrosis.