Restoring the thiocyanate levels in β-ENaC overexpressing mice, a model for CF [70], using nebulized thiocyanate decreased the bacterial burden after Pseudomonas aeruginosa infection and attenuated neutrophil infiltration and reduced the levels of the chemokine CXCL1 and cytokines IL-6 and TNF-α in the BAL [299]. This evidence concerns the gene CXCL1 and cystic fibrosis.