From the listed proteases the bacterial proteases (periodontain, aureolysin, and thermolysin) and the human matrilysins (MMP7, MMP26) are of special interest, since they have been shown to efficiently cut AAT at Phe352-Leu353, therefore contributing to the generation and amplification of CAAP47/48 in the context of sepsis [12, 37–43]. Here, SERPINA1 is linked to Sepsis.