Of particular note, GAD67 (aka Glutamate Decarboxylase 1, 67kDa isoform), encoding the enzyme which converts glutamate to GABA, is down-regulated in both the hippocampi (Benes et al., 2007) and cortices (Hashimoto et al., 2003) of schizophrenia patients and the medial pre-frontal cortices of rats injected with MK-801 on PND 7 and socially isolated post-weaning (Gilabert-Juan et al., 2012). The gene discussed is GAD1; the disease is schizophrenia.