NOS3 and portal hypertension: Recently we have also demonstrated that compound 6 exerts portal pressure-lowering effects in rodent models of portal hypertension by directly regulating the expression/activity of cystathionine γ-lyase (CSE) and endothelial nitric oxide synthases (eNOS) in liver sinusoidal endothelial cells (LSEC), thus affirming this compound as a novel approach to attenuate the hemodynamic changes in patients with liver cirrhosis35.