SELPLG and type 2 diabetes mellitus: Consistent with previous observations that leukocyte rolling time is critical for firm adhesion in leukocyte recruitment56, the observed neutrophil phenotypic changes in T2DM patients can potentially impair initial neutrophil capture, PSGL-1 mediated signaling57, as well as cell arrest through β2 integrins58, thereby leading to defective neutrophil-endothelial interactions during inflammation.