Higher neutrophil rolling speed was observed in T2DM patients (P < 0.01), which strongly correlated with neutrophil intracellular reactive oxygen species (ROS) level, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as well as established cardiovascular risk factors (cholesterol, high-sensitive C-reactive protein (CRP) and HbA1c). Here, SELPLG is linked to type 2 diabetes mellitus.