Average rolling speed was strongly correlated to neutrophil ROS level (Fig. 5D) and PSGL-1 expression (P < 0.001) (Fig. 5E) but not CD11b (Fig. S6) in both healthy subjects and T2DM patients, suggesting a key role of PSGL-1 in mediating leukocyte rolling during inflammation. Here, ITGAM is linked to type 2 diabetes mellitus.