As neutrophil dysfunctions have been reported previously in T2DM patients15, 16, 38, we first performed immunophenotyping in healthy subjects (n = 16) and T2DM (n = 16) patients using flow cytometry and C-reactive protein (CRP) measurement, a key marker for low-grade inflammatory state and cardiovascular risk (summarized in Table 1). The gene discussed is CRP; the disease is type 2 diabetes mellitus.