SRC and neoplasm: Interestingly, SRC histology (multivariable Cox HR, 2.37; 95% CI, 1.42 to 4.26; P = 0.033), age (multivariable Cox HR, 1.03; 95% CI, 1.02 to 1.05; P < 0.001), vascular invasion (multivariable Cox HR, 2.16; 95% CI, 1.41 to 3.30; P < 0.001) and increasing AJCC and tumour stages (Supplemental Table 6) were significantly associated with relapse-free survival.