CASP3 and lung adenocarcinoma: Yang et al. observed that CCNL2 exerts direct antiproliferative effects on A549 human lung adenocarcinoma cells by inducing cell apoptosis in vitro and that overexpression of CCNL2 induced an increase in caspase-3 in A549 cells at 24 h post-transfection compared with mock vector transfection35.