Albeit the higher IOD score and wider range (mean ± SD: 19530 ± 9741 in peritumor vs 15699 ± 9255in tumor, respectively, P < 0.001, Fig. 1G), we ruled out the necessity of further analyzing peritumoral C5a in its prognostic properties, as the minimum P value was 0.75 by X tile. Here, C5 is linked to neoplasm.