EDN1 and hereditary clear cell renal cell carcinoma: We noticed that several stress response genes such as Drr1 (down-regulated in renal cell carcinoma 1, also called family with sequence similarity 107 (Fam107A)), Edn1, Klf9, and Nfkbia39, 40, 41, 42 were significantly increased in Cpeb4GT/GT spinal cord (Fig. 5A), which was independently validated by RT-qPCR (Fig. 5B).