CACNA1A and Ataxia: For example, a similar drug to 4-AP, 3,4-diaminopyridine (DAP), has been shown to improve other motor symptoms, like downbeat nystagmus, in human ataxias including SCA636, and also improves Purkinje cell firing rate and motor coordination deficits in SCA1 mice21, making DAP an interesting drug to study in SCA6 as well.