CDK6 and type 2 diabetes mellitus: As shown in Fig. 1D,E, in human β-cells from normal and T2D donors, p27KIP1 was detected more often in the nuclei of T2D β-cells as compared to normal β-cells, both under basal conditions, as well as when cell cycle entry was induced by cdk6 and cyclin D3 overexpression (Fig. 1D,E).