The international literature suggests that hypoglycaemia is poorly recognised by many at-risk diabetic patients on insulin and/or sulphonylureas.6,7,8,13 A national online survey in 2011 amongst 2530 adult patients with type 2 DM done in San Diego in California in the United States showed that many patients were unable to list the leading causes of hypoglycaemia; 27% of patients did not know that skipping meals could cause hypoglycaemia and 35% did not know that some diabetic medications could increase the risk of hypoglycaemia. The gene discussed is INS; the disease is Hypoglycemia.