Moreover, Vella et al. [42] reported that insulin resistance surrogates, such as HOMA-IR, were associated with cardiovascular disease risk in Hispanic normal weight women; in this regard, our team previously published that as HOMA2-IR increased, so did cardiovascular risk calculated with a correction of the Framingham-Wilson equation, being highest in insulin resistant subjects [43]. The gene discussed is INS; the disease is Insulin resistance.