TGF-β1 treatment could increase acetylation of histone (H3K9, H3K14, and H3K27) as well as Ets-1 in mouse renal glomerular mesangial cells; furthermore, acetylation of Ets-1 and histone H3 was increased in glomeruli from diabetic db/db mice also, both of which can increase miR-192 expression contributing to DN [35]. The gene discussed is ETS1; the disease is liver dysplastic nodule.