EP300 and liver dysplastic nodule: Curcumin, the p300/CBP inhibitor [59], extracted from rhizomes of turmeric Curcuma longa [60], which was supposed to be a new target molecule for treating CNS disorders and cancer [61, 62], was firstly reported to prevent the development of DN involved in the changes of PTMs of histone H3 including acetylation and phosphorylation and the changes in HSP-27 and p38 expression in diabetic rats [40].