A recent study showed that HDAC1 was significantly decreased in the renal cortex of Akita mice, while the levels of HDAC2 in Akita and WT mice were unchanged, and HDAC1 was significantly decreased in HG-cultured HBZY-1 cell, which can upregulate diabetes-, HG-, and NaB-induced histone hyperacetylation leading to inflammatory factors elevation associated with DN [33]. Here, HDAC2 is linked to liver dysplastic nodule.