Curcumin could also prevent HG-induced key ECM genes and vasoactive factors (eNOS and ET-1) expression levels associated with DN in endothelial cells [56]; it was able to reverse the upregulation of vasoactive factors, TGF-β1 and ECM protein FN in STZ-induced diabetic kidneys, which was associated with p300 and NF-κB activity changes [63]. The gene discussed is EP300; the disease is liver dysplastic nodule.