A recent study revealed that acetylation of H3K9, H3K18, and H3K23 were significantly increased in the renal cortex of Akita mice, HG and NaB-induced H3K9 and H3K18 acetylation was elevated in the mesangial cells also, which were associated with inflammatory factors such as MCP-1, ICAM-1, VCAM-1, and iNOS expression linked to the development of DN [33]. Here, CCL2 is linked to liver dysplastic nodule.