P/CAF was found sharply increased in the renal cortex of Akita mice, while GCN5 was significantly decreased in the HG group, suggesting that the inflammatory genes expressions were related to DN [33]. In vivo and in vitro results of another report showed that p/CAF was closely related to H3K18Ac levels at inflammatory molecules ICAM-1 and MCP-1 promoters, which could be a potential therapeutic agent for inflammation-related renal diseases including DN [57]. The gene discussed is ICAM1; the disease is liver dysplastic nodule.