It was implicated that p300 played important roles in oxidative stress-induced PARP and NF-κB signaling in HG-treated endothelial cells and diabetic kidneys [53–55]; further study showed that HG upregulated p300, which increased HAc at promoters of key ECM protein FN, as well as vasoactive factors such as ET-1 and VEGF in endothelial cells [56]. The gene discussed is EP300; the disease is diabetes mellitus.